Evaluation of anti-inflammatory activity of plant lipids containing
alpha-linolenic acid.
Singh S, Nair V, Jain S, Gupta YK
Indian J Exp Biol 2008 Jun; 46(6):453-6.

Two groups of fatty acids are essential to the body, the omega6 (n6)
series derived from linoleic acid (18:2, n-6) and the omega3 (n3)
series derived from alpha-linolenic acid (18:3, n-3).
Fatty acids provide energy, are an integral part of the cell membranes
and are precursors of prostaglandins, thromboxanes and leukotrienes
collectively known as eicosanoids.
Eicosanoids participate in development and synthesis of immunological
and inflammatory responses.
The fixed oils (1, 2, 3 ml/kg) containing alpha-linolenic acid,
obtained from the seeds of Linseed (Linum usitatissimum), Soyabean
(Glycine max) and Holy basil (Ocimum sanctum) were screened for their
antiinflammatory activity using carrageenan, leukotriene and
arachidonic acid induced paw edema models in rats and the
antiinflammatory effects were compared with the standard drug
indomethacin.
Significant inhibition of paw edema was produced by all the oils in
the highest dose (3 ml/kg) in all the models. While O. sanctum oil
produced the maximum percentage inhibition in leukotriene induced paw
edema, L. usitatissimum oil produced maximum percentage inhibition in
carrageenan and arachidonic acid induced paw edema models.
The results show that oils with higher alpha-linolenic acid content
(L. usitatissimum and O. sanctum) produced a greater inhibition of paw
edema suggesting that modulation of the course of inflammatory
disorders may be achieved by altering the eicosanoid precursor (i.e.
poly unsaturated fatty acids: PUFA) availability through dietary
manipulation.

Indian journal of experimental biology [Indian J Exp Biol]
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Alpha-linolenic Acid From Plants

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On Aug 26, 8:44 pm, ironjustice <teamtan...@hotmail.com> wrote:alpha-
linolenic acid <<

"COX-1 and -2 inhibitory activity"

Isolation of linoleic and alpha-linolenic acids as COX-1 and -2
inhibitors in rose hip.
Phytother Res 2008 Apr 3.
Jäger AK, Petersen KN, Thomasen G, Christensen SB

Rose hip has previously shown clinical efficacy in the treatment of
osteoarthritis, and organic solvent extracts of rose hip have showed
inhibition of cyclooxygenase-1 and -2.
A petroleum ether extract of rose hip was fractioned by VLC on silica;
on a C-18 column and by HPLC.
Each step was COX-1/2 activity-guided.
The bioassay-guided fractionation led to the isolation of linoleic
acid (the IC(50) for COX-1 was 85 microm and 0.6 microm for COX-2) and
alpha-linolenic acid (the IC(50) for COX-1 was 52 microm and 12 microm
for COX-2).
The COX-2/COX-1 ratio was 0.007 for linoleic acid and 0.2 for alpha-
linolenic acid. Linoleic acid and alpha-linolenic acid contribute to
the COX-1 and -2 inhibitory activity of rose hip.
Copyright (c) 2008 John Wiley & Sons, Ltd.

Phytotherapy research : PTR [Phytother Res]
--------------------------------------------------------------------------- -----

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