"COX-1 and -2 inhibitory activity"

Isolation of linoleic and alpha-linolenic acids as COX-1 and -2
inhibitors in rose hip.
Phytother Res 2008 Apr 3.
Jäger AK, Petersen KN, Thomasen G, Christensen SB

Rose hip has previously shown clinical efficacy in the treatment of
osteoarthritis, and organic solvent extracts of rose hip have showed
inhibition of cyclooxygenase-1 and -2.
A petroleum ether extract of rose hip was fractioned by VLC on silica;
on a C-18 column and by HPLC.
Each step was COX-1/2 activity-guided.
The bioassay-guided fractionation led to the isolation of linoleic
acid (the IC(50) for COX-1 was 85 microm and 0.6 microm for COX-2) and
alpha-linolenic acid (the IC(50) for COX-1 was 52 microm and 12 microm
for COX-2).
The COX-2/COX-1 ratio was 0.007 for linoleic acid and 0.2 for alpha-
linolenic acid. Linoleic acid and alpha-linolenic acid contribute to
the COX-1 and -2 inhibitory activity of rose hip.
Copyright (c) 2008 John Wiley & Sons, Ltd.

Phytotherapy research : PTR [Phytother Res]
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